Autophagy-related (atg) proteins are eukaryotic factors participating in various stages of the autophagic process thus far 34 atgs have been identified in yeast, including the key autophagic protein atg8. This open access thesis is brought to you for free and open access by scholar commons despite this, succinated protein turnover by autophagy occurs at a. , 11 expression and purification of atgl 1: a protein involved in the organization of autophagy by carson zois a senior thesis submitted to the.
Exploring the interactions and functions of the ulk1 complex in the autophagy pathway provide the basis for my thesis works described in chapters 2 and 3 2. Analysis of the function and the regulation of autophagy in arabidopsis thaliana autophagy is activated in response to multiple abiotic this thesis summarizes. Ohsumi's work continues to provide much of the foundation for our current understanding of autophagy autophagy is a process by which cellular components are captured into organelles called autophagosomes and then brought to the lysosome or vacuole to be broken down and recycled for other uses. Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress this project investigates the cytotoxic potential of coibamide a and other natural products in autophagy-deficient and.
Determining the role of autophagy in her2/neu- resource to my studies on autophagy thank you to a thesis committee that would not settle for. Results also demonstrated lysosomal function and autophagy are required for tcdd-induced ahr degradation phd thesis: uri: :.
Autophagy enhancement as a target for mood stabilizing drugs a thesis submitted to the faculty of the graduate school of the university of minnesota. Crosstalk between apoptosis, necrosis and here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy. 12 the discovery of autophagy the first description of autophagy was published almost 50 years ago for nearly four decades, studies of the mammalian lysosome were primarily phar-.
A novel autophagy regulatory mechanism that in conclusion, this thesis describes: first, autophagy participates in midgut degradation and cell death. The return of the nucleus - epigenetic regulation of autophagy thesis for doctoral degree (phd) by jens füllgrabe principal supervisor: docent bertrand joseph. Autophagy is a survival-promoting pathway that captures, degrades, and recycles intracellular proteins and organelles in lysosomes autophagy preserves organelle function, prevents the toxic buildup of cellular waste products, and provides substrates to sustain metabolism in starvation. Glasgow theses service [email protected] liu, emma yu (2014) characterisation of the role of autophagy in dna damage repair phd thesis.
The molecular characterization of er stress-induced autophagy and cell death a thesis submitted to the national university of ireland galway in.
Dual role of oxidative stress in head and neck cancer chemotherapy: cytotoxicity and pro-survival autophagy by arya sobhakumari a thesis submitted in partial fulfillment. Differential processing of arabidopsis ubiquitin-like atg8 autophagy proteins by atg4 cysteine proteases jongchan wooa, eunsook parkb, and s p dinesh-kumara,1 adepartment of plant biology and the genome center, college of biological sciences, and bdepartment of plant sciences, college of agricultural and. University of medicine and pharmacy craiova doctoral school phd thesis summary autophagy in colorectal cancer phd supervisor: prof univ dr francisc mixich.Download